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SMC model

This page contains downloads and information associated with the paper: Corrias A & Buist ML. A quantitative model of gastric smooth muscle cellular activation. Ann Biomed Eng, 35(9):1595–1607, September 2007.

This mathematical model defines a physiologically realistic quantitative description of smooth muscle cellular electrophysiology. We provide further data here in support of the above publication, primarily based on a CellML encoding of the model written by Alberto Corrias. We provide:

These files can be used to reproduce the results published in the paper. The following figures were generated using the CellMLSimulator software to generate the graphical outputs. These models reproduce the numerical experiments presented in Figure 4 and 5 of the Corrias & Buist (2007) article.

smc_control icc_stim
SMC membrane potential (left) in response to an ICC stimulus (right)
AP_Cai AP_IKr
SMC intracellular calcium concentration (left) and delayed rectifier potassium current(right) during a slow wave
AP_ICa AP_INa
SMC calcium (left) and sodium (right) currents during a slow wave
AP_IKA AP_IBK
SMC A-type (left) and calcium activated (right) potassium currents during a slow wave