Jejunal SMC model

Human jejunal smooth muscle model

This page contains downloads and information associated with the paper: Poh YC, Corrias A, Cheng N and Buist ML. A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology. PLoS ONE 7(8): e42385, August 2012.

This study proposes a model of human jejunal smooth muscle cell electrophysiology. This is the first biophysically based model of an intestinal SMC, and the first model of a human GI cell. The resulting cellular description is able to reproduce experimentally recorded slow wave activity and produces realistic responses to a number of perturbations, providing a solid platform on which the causes of intestinal myopathies can be investigated. Various implementations of the model were prepared by Poh Yong Cheng and provided below:

A CellML file
C format;
Matlab derived from the CellML version with the help of COR.

The following selected figures were generated from COR using the hJSMC model encoded in CellML.

jejunalsmc_control

Simulated electrical slow waves of the human jejunal smooth muscle cell model (hJSMC). This figure reproduces Figure 8 of the paper.

jejunalsmc_calcium

Free intracellular calcium concentration during a simulated electrical slow waves of the human jejunal smooth muscle cell model (hJSMC). This figure reproduces Figure 8 of the paper.